The title is a play on the series God Friended Me (2018), which features Violett Beane, who played Jesse Wells in seasons 2 and 3, as Cara Bloom, one of the lead characters. The executive producer of that show, Greg Berlanti, is also executive producer/developer of all the Arrowverse shows.
The merged form of Barry and Grodd, which grants Grodd access to the Speed Force and shows a lightning bolt painted on his chest, is a nod to Grodd's design following the New 52 reboot in 2011.
In a reference to Supergirl now living on the same Earth as them, Chester says "Thank Rao!" at one point.
Cisco and Ralph are both absent, the former still on his fact-finding mission and the latter hunting down Sue. However, Cisco does call Kamilla to tell her he's coming home.
Solovar's first appearance in the series post-Crisis. In the original "Crisis" comics, Solovar is one of the individuals that Harbinger recruits to help stop the Anti-Monitor.