In the Sickbay scene, before Paul Stamets is awakened, the sounds are the same Sickbay sounds from the diagnostic bed(s) in Star Trek (1966).
Since the season opener was originally announced as "That Hope Is You: Part 1", it was suspected that this episode would be named "That Hope Is You: Part 2".
First Star Trek episode ever without a white straight male speaking human character as part of the main bridge crew.