Hugh Laurie was nominated for the Emmy of Outstanding Lead Actor in a Drama Series for his performance as Dr. Gregory House in this episode.
One of the first songs that Dr. House plays that is copied by Dave Matthews' character is the intro from "I Don't Like Mondays" by The Boomtown Rats.
Actor Kurtwood Smith, who plays the father of Dave Matthews' character, previously played Robert Sean Leonard's (Dr. James Wilson) father in Dead Poets Society (1989), in which he wanted his son to become a doctor.
House's fake name for his medical records is Luke N. Laura, a reference to the popular couple from the American daytime drama General Hospital (1963).
In That '70s Show (1998), Kurtwood Smith's character had a son named Eric Forman; in this series, Eric Foreman is one of the doctors on House's team.