Hugh Laurie was nominated for the Emmy of Outstanding Lead Actor in a Drama Series for his performance as Dr. Gregory House in this episode.
One of the first songs that Dr. House plays that is copied by Dave Matthews' character is the intro from "I Don't Like Mondays" by The Boomtown Rats.
In Patrick's hospital room, House wheels in a piano. The piece of music that he says he wrote in high school is actually a score entitled "I Have No Memory" by Slacker (Shem McCauley).
Actor Kurtwood Smith, who plays the father of Dave Matthews' character, previously played Robert Sean Leonard's (Dr. James Wilson) father in Dead Poets Society (1989), in which he wanted his son to become a doctor.
House's fake name for his medical records is Luke N. Laura, a reference to the popular couple from the American daytime drama General Hospital (1963).
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