Actress Pamela Brumley, from the original film, was not available, so during the opening scenes of Sarah's departure, the character of Nikki was doubled by a combination of two actresses - Kendall Rutledge supplied the voice, and Tara Wallace served as body double.
The airport coffee shop scene was filmed inside an actual building with an open air coffee shop. To process the illusion of hundreds of airline travelers passing on all sides, a finite number of background actors did "laps" around the outside of the restaurant, changing costumes and props in the areas not in camera frame, so as to appear to be different characters each time.
The airplane used in the flight sequences is actually a full-size 737 used for training purposes at the Vincennes University Aviation Technology Center in Indianapolis.
Novelist David Gregory, author of 'A Day with a Perfect Stranger', upon which the movie is based, appears on the airplane as the voice of the captain.
On the last day of filming, star Ruby Lewis, along with several members of the crew, became ill with flu-like symptoms. The production coordinator had to put on Lewis' costume and stand in for her on the cutaway shots of Sarah sketching on the airplane.