The brain animation sequence was shot in producer Blake Myers' kitchen at 610A Woodward Ave. The animation table blocked the only entrance to the bathroom, causing discomfort for animators Tak Masuda and Blake Myers.
The cut-out animation sequence was shot in one all-night session in the attic of the director's father's dental lab.
The drawing animation sequence was shot in three consecutive all-night sessions with a rotating crew while drinking pots of coffee, smoking fifteen packs of cigarettes, and Amy Jackson losing her mind.
The interior of Room 101 was shot in a basement of a former crack house in Atlanta, GA.