This marked the first appearances for Julie Adams, Kathryn Grayson, Ruth Roman and Sally Klein as Eve Simpson, Ideal Malloy, hairdresser Loretta Spiegel and manicurist Corrine respectively as well as Loretta's Beauty Shop. Loretta's would become a hangout for the ladies of Cabot Cove.
The title is an allusion to the film If It's Tuesday, This Must Be Belgium (1969). The film follows a group of travelers on a trip across seven European countries in 18 days.
The character of Eve Simpson, played by Julie Adams, appeared in 10 episodes from Season 4-9. Eve Simpson was the local real estate agent in Cabot Cove.
Rick Lenz (Detective Jonathan Martin) also appeared in S12.E19 "Evidence of Malice" as a different character (Isaac Meecham). Lenz stopped acting in 2003.
Gloria DeHaven played the character of Phyllis Grant in three episodes (S4.E7, S5.E17, S6.E11).