Dan complains that the Black Hills Pioneer doesn't publish baseball scores, and mentions that a new league has started a team in Chicago. He's referring to the Chicago Cubs, one of the founding teams of the National League. They played for the first time in 1876.
Doc and Jane really did tend to the people of Deadwood when smallpox broke out. It was documented that Jane helped save the lives of many people in town, along with a description of her rough-and-tumble appearance in Estelline Bennett's Old Deadwood Days.
The Lakota warrior whose grave Bullock disturbs is missing his head. Although it is never stated explicitly, the implication is that this is the man whose severed head is brandished in the streets of Deadwood after Al offers a bounty in the pilot episode.
David Milch disliked the choreographed fight scene between Seth Bullock (Timothy Olyphant) and the Native American warrior (Juddson Keith Linn) created by the stunt coordinators, finding a fist fight unrealistic in this scenario. It was scrapped at the last minute and Linn recalled the native dance and song from his childhood in Oklahoma. Milch proposed Olyphant holding onto the dancing man's leg, causing him to lose his balance instead.
Parisse Boothe (Tess) plays her first of 5 episodes in the Deadwood series. She is the daughter of Powers Boothe (Cy Tolliver).