The first basic cable series to be nominated for a Golden Globe for Best Television Series - Comedy.
For the first five seasons, Monk's preferred brand of bottled water was Sierra Springs (a real-life brand of bottled water), and his refusal to drink any other water was an important plot point in several episodes. In season six, ostensibly due to a contract termination between Sierra Springs and USA Network, the brand of water was changed to the fictional "Summit Creek".
On March 13, 2023, Tony Shaloub announced during an interview that there will be a reunion movie and shooting is scheduled to begin in May 2023. It will address Monk's life after the pandemic. Monk in Quarantine (Mr Monk Shelters in Place) was a timely, caring and utterly hilarious short, showing a snapshot of Monk coping with the pandemic, and his friends trying to cope with his plague-averse hygiene excesses. (Still available on YouTube.)
Tony Shalhoub's wife, Brooke Adams, appeared five times, playing a different character four times.
- Mr. Monk and the Airplane (2002) (#1.16) as a flight attendant named Leigh Harrison.
- Mr. Monk and the Kid (2005) (#3.16) as Mrs. Abigail Carlyle.
- Mr. Monk Visits a Farm (2007) (#5.14) as Sheriff Marge Butterfield.
- Mr. Monk's 100th Case (2008) (#7.7) as Leigh Harrison again.
- Mr. Monk and the Badge (2009) (#8.14) as Edith Capriani the crazy cat woman.
Tony Shalhoub (Adrian Monk) is the only actor to appear in all 125 episodes of the series. In second place is Jason Gray-Stanford (Lieutenant Randall Disher), who appeared in every episode except for: