Mal has second thoughts after discovering that two boxes of Alliance goods his crew has been hired to steal are full of badly needed medical supplies headed for the mining town of Paradiso.
Serenity is pulled in by an Alliance cruiser while investigating a spaceship that was attacked by Reavers. Simon and River must hide to prevent capture, while something is wrong with the lone survivor of the attacked spaceship.
The crew has a job in a town where Jayne once robbed the magistrate but dropped the stolen money, making him a local folk hero, and a target for the local boss.
In order to secure a job transporting cargo off-planet for a client, Mal attends a social event where a dance with Inara leads to him being challenged to a swordfight in defense of her honor.
Mal must choose which crew members to save when one is gravely wounded and two others are kidnapped. Simon finds an uneasy haven in a remote village, but River's uncanny perceptions jeopardize the Tams' temporary safety.
Serenity encounters a ruthlessly professional bounty hunter, Jubal Early, who will stop at nothing to retrieve River. But River, feeling unwelcome on the ship, takes a novel approach to escaping from the Alliance.
Malcolm Reynolds is a veteran and the captain of Serenity. He and his crew are smuggling goods, but they need to pick up some passengers for extra money. However, not all the passengers are what they seem.
A Companion-trained friend of Inara's who runs a brothel on a remote planet calls for help from Serenity when a local reveals his intentions to take the baby from a woman he impregnated.