Besides guest starring in a couple of episodes of The Simpsons, Globehunters is the animated feature film debut of Willem Dafoe, who starred as Hunter in this movie. He would later go on to star in Finding Nemo as a supporting character named Gill.
Chaka Khan would later go on to guest star as herself in Phineas and Ferb: Summer Belongs to You.
This film is the second film Carl Reiner voice acted in.
Chaka Khan would later go on to guest star as herself in the Phineas and Ferb episode "Summer Belongs to You!"