Lucky and the pups climb aboard a spaceship which takes off into space. When several of Cadpig's casual predictions come true, everyone is convinced that she is a psychic.
Cruella is competing with Nanny to be named "Humanitarian of the Year." To win she fakes doing good deeds and hides a box of incriminating photos. The pups show her true colors.
When Anita and Cruella's nieces compete in a beauty pageant, Cruella and her goons conspire to help Ivy win. A bored Dumpling follows the pups around and becomes a nuisance.
Cruella goes undercover to find out about two women she is making fashions for without her knowledge. Lucky injures himself and is forced to wear a cone.
Anita locks her keys in the car, causing a traffic jam and catching the attention of the news. Lucky fears he's losing his luck when his horseshoe spot disappears.
Cruella enters her new show dog, Vendela de Vil, in the Grutely Dog Show. Tired of being suckered by Mooch, Rolly gives him a taste of his own medicine by becoming a con artist.
When Cruella fires Horace and Jasper for their latest bungle, they go to an employment agency looking for their next job. They end up getting a job dog sitting for the Dalmatians.
Roger, Anita and the main pups discover an old town owned by one of Cruella's relatives only to discover it is cursed, and now it's up to Spot to save the day.
Lucky falls into a cave and discovers a prehistoric cavepup which Cruella plans to exploit. Mooch's love for Cadpig makes him soft right before an important wrestling match.
Rolly notices that the dog food tastes different and finds out Cruella may have had something to do with it. Spot's wish to become a dog is granted by her fairy god-chicken.
Cruella has a "good" clone made. While the humans, Pongo and Perdita are away, the pups must defend the Dearly home from Swamp Rat, who has turned it into a gambling den.
Cruella and the pups crash Roger and Anita's vacation. To their surprise, they realize their marriage was never official and Cruella sees this as an opportunity to seize the farm.
The Dearlys get stranded in the desert. Horace and Jasper, disguised as baseball scouts, trick Roger into signing a contract and make Anita think he's leaving her to play baseball.
