The movie was shot on location in New Orleans and the house where Judy and Mona lived was located at 3901 St. Charles Avenue. It was demolished in the late 1960s or early 1970s to make way for construction of the seven-story St. Charles Gardens apartment building sometime in the early 70s. The building and its parking lot occupy the entire block of St. Charles Avenue (between General Taylor Street and Constantinople Street) where three other homes also once stood: 3915, 3923, and 3931 St. Charles Avenue. Across the street, the Rayne Memorial United Methodist church (shown briefly as the ambulance is pulling away at the 1:35 mark) is still standing.
The route from inside the ambulance as it traveled to the hospital was shot along the 400-900 blocks of Carondelet Street.
Of course Bourbon Street is, well, still Bourbon Street, and the hospital shown at the end of the movie when
Judy and her fiancé reunite is Charity Hospital at 1532 Tulane Avenue. It sustained major damage from Hurricane Katrina and is still vacant, but there are plans afoot to rehabilitate it and redevelop the site for use as the flagship building for the Tulane University School of Public Health and Tropical Medicine.