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Two years after the death of the extraterrestrial Sil (in Species), Dr Laura Baker (Marg Helgenberger) has successfully cloned another Sil from a frozen embryo. Named Eve (Natasha Henstridge), she has been raised surrounded only by human females and willingly submits to tests to determine her vulnerabilities in order to defend mankind from future invasions. Meanwhile, during the first manned space landing on Mars, astronaut Patrick Ross (Justin Lazard) becomes infected with alien DNA from a soil sample he collected for analysis. When he returns to Earth, he begins to mutate and to breed, rousing the previously docile Eve via a telepathic link. Consequently, Dr Baker and diplomatic security specialist Preston Lenox (Michael Madsen) must once again hunt down and destroy the new threat.

Species II is a sequel to Species (1995) (1995). The screenplay for Species II was written by American screenwriter Chris Brancato based on characters created by Dennis Feldman for the first movie. A novelization, also titled Species II (1998) and written by American author Yvonne Navarro, was released concurrently with the movie. Species II was followed by Species 3 (2004) (2004) and Species 4: Das Erwachen (2007) (2007).

While doing research on the fossils in a Mars meteorite, Dr Herman Cromwell (Peter Boyle) discovered evidence of carbon-based elements that only exist in the Magellanic Galaxy, 100 million light-years away, and theorizes that Mars was visited by an alien species about a billion years ago and that it was this species that turned Mars into the useless hunk of rock that exists today. He warned against the Mars space mission on the grounds that the astronauts might be contaminated with the alien DNA, but the government was gung ho on using Mars as an outpost. Because of his opposition, Cromwell was fired from his position at Stanford University, declared insane, and placed in the Garberville Psychiatric Institute.

Dennis Gamble's genes carried the sickle cell anemia trait, but he does not have sickle cell anemia. This disorder causes the body to make sickle (or crescent) shaped red blood cells instead of the round, doughnut (without the hole) shaped cells of normal blood. Apparently, the alien DNA could not bond with Gamble's DNA under those circumstances, as they cannot handle our genetic diseases.

This part is a bit confusing as there was no explanation given. In the commentary, the director says that it was an "arm" belonging to Patrick. He was beginning to suspect there was something wrong with him (he'd already asked his father, Senator Judson Ross (James Cromwell), for help and was told to suck it up), so he went to retrieve his alien-infected blood in order to cover up any evidence of his infection. He "called" to his blood, causing the vial to fall to the floor and stream toward and up the wall behind which he was hiding. When the doctor got close to the wall, Patrick jammed his arm through and killed him, knowing that Orinsky had already learned of his infection.

No. Dr. Baker compares Eve's DNA to the substance found in Orinsky's wounds and concludes that they are structurally similar but not a perfect match. This is like comparing two human blood samples. It would be easy to identify them as structurally human, but variations in the DNA would reveal that they are not from the same individual. This tells Baker that there is another human/alien hybrid out there.

Not exactly. No Mars based meteorite was found in 1996. However, after the Allan Hills 84001 meteorite, found in 1984 in Allan Hills, Antarctica and thought to be from Mars, was subjected to thorough research, it was announced in 1996 by NASA astrobiologist David McKay that it contained microfossils, evidence of ancient Martian bacteria.

Although Eve was electronically tethered to a control box that would set off a bomb in her brain should she ever escape, she is shown demolishing the tether manually by smashing it during its countdown just before it reaches activation.

Baker and Press follow Eve to the shed where Patrick's hybrid offspring have entered the cocoon stage. While they spray the cocoons with a toxin made from Gamble's blood, Eve and Patrick transform into their alien forms and begin to mate. Press goes after Patrick, who changes into his another alien form after coming out of the mating cocoon, while Baker pleads for Eve to help them. Eve tries, but Patrick seemingly kills her. Patrick then turns on Press, while Baker keeps spraying him with the toxin. With Gamble's consent, Press stabs his leg with a pitchfork, then thrusts the pitchfork into the Patrick creature, innoculating him with Gamble's blood and killing him. In the final scene, the military arrives to escort Press, Laura, and Dennis away. Eve's body is placed in an ambulance. From out of nowhere, a cat jumps on her body. In the corner, one of Patrick's offspring is shown hiding. In the final scene, Eve's abdomen begins to swell.