Almost every element from the George of the Jungle (1967) cartoon series is included in this movie... even the "Never argue with the Narrator" line that shows up in Jay Ward's cartoons.
Brendan Fraser's personal trainer for the film sued Fraser for not mentioning him in the credits. The trainer did not win the case.
During a 2019 interview on Ocupado esta noche (2018), co-star Leslie Mann confessed that she developed a real-life crush on Brendan Fraser during filming and ultimately fell in love with him. She was then surprised by Brendan, hiding on set.
It was after seeing this film that director Stephen Sommers considered Brendan Fraser for the role of Rick O'Connell in La momia (1999).
This film's production designers added an automatic juicer, elevator, love seat swing, comfy hammocks and running water in George's tree house. These props for this set were at a former hangar of the Howard Hughes Airport.