A giant lizard has been spotted in the subways and Jameson is willing to pay $1,000 to the photographer who gets the creature on film. Peter turns to his college professor, Dr. Curt Connors, for answers. But not the answers he expects.
Spencer Smythe's son Alaster is hired by the Kingpin to get revenge on Spider-Man and everyone who had a hand in Spencer's death. He rebuilds the original Spider Slayer, along with two more.
Doctor Otto Octavius, one of Peter's childhood teachers, gets revenge on the Hardy family for cutting off the funding for his research, by kidnapping Mrs. Hardy's daughter, Felicia.
Jameson is becoming obsessed with destroying Spider-Man. So he hires a man named Mac Gargan to try out a new scorpion suit, made in the laboratories of Empire State University. But the mutation of the suit begins to turn Gargan into a monster.
Peter has a job interview at the Hardy Foundation Research Center. But his interviewer, Dr. Mariah Crawford, is visited by an old lover, Sergei Kravinoff aka Kraven the Hunter.
The beginning of the Alien Costume saga; how it came from the surface of the Moon to New York City and into the life of the one who saved the astronauts of the space mission: Spider-Man.
Spider-Man is becoming attached to his new suit. But Eddie Brock has framed Spider-Man for the Promethium X robbery. Alaster and Kingpin send Shocker after Eddie to dispose of him. Now, Spidey will begin to see what the suit is really worth.
The symbiote takes over Eddie Brock to give birth to Venom. Now, Spidey must go up against the most dangerous enemy he's ever faced. One who is stronger, more skilled, undetected by his spider-sense, and knows Spidey's true identity.
Norman Osborn hires a psychopath, known as the Hobgoblin, to kill the Kingpin. But the Hobgoblin plans to use Osborn and Kingpin's rivalry to his own advantage.