Dr. Dawn 'Holli' Holiday, a Los Angeles forensics expert, is vacationing in Hawaii with an old flame, when she discovers a body and investigates with a Honolulu cop.
A U.S Marshall with whom Holli has previous involvement is paid by an obstreperous Colombian drug lord to kill a mob hit-man in witness protection and switch the hit-man's identity to the Colombian.
A man trying to hide an affair and special forces operative stalking his ex-wife escape Holli's attempt to contain for inoculation the passengers of a flight on which a man has died of bacterial meningitis.
The offices of the D.A. and Medical Examiner offices are frustrated by preferential treatment given a popular island singer accused of murder at the same time an elite defense team tries to demean Holl's forensic evidence including DNA.
