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Switchblade Sam is the second character that Christopher Lloyd played for which Tim Curry was first considered. The casting team of ¿Quién engañó a Roger Rabbit? (1988) had also considered Curry to play Judge Doom before Lloyd was ultimately cast.
According to Christopher Lloyd, after filming the scene where his character spears Gunther's apple with a knife and eats it, Hank Johnston, the young actor playing the role, was so frightened of Lloyd that he wouldn't approach him afterwards on the set.
During his first audition, Mason Gamble pulled a live worm out of his pocket. This spontaneous move inspired the casting directors to cast him.
Over 20,000 little boys auditioned for the titular role of Dennis Mitchell. Ten were selected to test the role with Walter Matthau.
During a Q&A in 2013, Christopher Lloyd stated that the scene where Switchblade Sam eats the beans, and jumps into the pond, was actually not in the original script.
Jeannie Russell: One of the Mitchells' neighbors. Russell had originally played the role of Dennis Mitchell's nemesis Margaret Wade on the classic TV series Daniel el travieso (1959).