The foam in the beer bottle on Babe Ruth's table disappears and reappears.
In the hospital scene, the doctor has a clipboard in his hand, then there is no clipboard, and then he has it again.
The position of Babe's fingers on the champagne glass during the Frazee-hosted party.
The film portrays Babe Ruth and Lou Gehrig as being enemies from the start. That is, in fact, not the case. When Gehrig first joined the Yankees, he and Ruth got along famously. They would often go on fishing trips and barnstorming tours together in the off season. The Ruth-Gehrig Feud did not start until after Gehrig had married Eleanor Twitchell in 1933.
Contrary to popular belief, Babe Ruth did not hit three home runs in his last game in 1935. While the three-homer game against the Pittsburgh Pirates did occur, Ruth actually retired in between games of a doubleheader against the Philadelphia Phillies a few days later. Babe grounded out in his final at-bat.
Babe Ruth and his first wife, Helen, never divorced because they were both Roman Catholics. They were separated when Babe played for the Yankees as he lived in New York and Helen lived in rural Massachusetts. Babe married Clare Hodgson just a few months after Helen died in a house fire.
The movie depicts Babe Ruth saying that he had a better year than the president in 1922. He actually made that quote in 1930, as he was talking about Herbert Hoover.
Jumpin' Joe Dugan says he got his nickname by "jumping" to whichever team will pay him the most. He actually earned the moniker by teammates due to his habit of taking unauthorized leaves from his team.
When young Babe is hitting against Brother Mathias, one of his shots is clearly hit down toward the ground, yet young Babe looks up as if he hit it some distance.
During the game in which Babe promised the sick child he would hit two home runs, the Yankees were batting in the top of the ninth. But the game was played at Yankee stadium and as home team they should have been batting second.
Early on, the Babe is seen arriving to a game at Fenway during the first inning, staggering hung-over to the plate, and hitting a home run. But this was a home game; it would have been the bottom of the first, and if Ruth hadn't been there by game time, another player would already have been playing in his place. He wouldn't have been able to just walk up to the plate and hit.
The Babe gets a pinch runner after hitting a home run although a pinch runner for a batter who has homered is against the rules.
On a train in 1925, Babe's daughter Dorothy is holding a doll. The doll is a modern 1980's porcelain doll.
Babe Ruth and "Jumpin Joe" Dugan are shown as teammates while on the Boston Red Sox in the movie. But Dugan didn't play for the Red Sox until 1921, when Ruth was already with the Yankees.
Wrigley Field outfield scenes show the "basket" that was not installed until 1970 to deter fan interference.
Wrigley Field's iconic ivy-covered walls are visible during the 1932 World Series, but the ivy was not planted until 1937.
When Ruth buys the farm while still a member of the Red Sox, the seller tells Ruth to "Get those Yankees." There was no big rivalry between the two teams at that time as the Yankees were not really seen as a viable threat to the Red Sox pennant chances. The Yankees-Red Sox rivalry did not really form until sometime after Ruth was sold to the Yankees.
The Miller Beer bottles that are depicted at the ballpark and at the diner when Babe first meets Helen are of the early 1990's model as in the 1910's, 1920's, and 1930's, Miller had shorter pony bottles.
After moving to New York at the party in their apartment, Helen's lips say "There are people f-ing in our bathroom" while the audio says "There are people, there are people in our bathroom"
Production assistant visible wearing basketball shoes and carrying walkie-talkie in the walkways under the baseball stadium.
As Babe drives along the street in pursuit of Helen, the camera and crew are reflected in a few of the store windows if you look carefully.
Visible in the windshield of the truck after Babe arrives at the farm. This is in the MIDDLE of the frame, and not at the top of the frame, as is usually the case.
Babe Ruth is depicted as being overweight on joining the Red Sox. However, contemporary photos show him to be of fairly normal build.
Babe Ruth was nowhere near as overweight as John Goodman when he was playing baseball.