Teri Weigel plays the part of a playmate. She was actually Playboy's Playmate of April 1986.
Just before Wilbur starts the flashback in his pizza shop, a newspaper clipping on the wall behind him praises Wilbur.
Steve Lundquist (Igor) appears in a Vidal Sassoon ad in the issue of Playboy George Clooney holds up.
On the wall behind Professor Ganreene right after he chews out Igor for interviewing the teddy bear, one of the clocks reads, "Lsa Vegas" and it has no hands. This could be a reference to the fact that Las Vegas casinos don't have clocks.
In the 2023 documentary, Screaming Soup! Presents the Attack of the Killer Tomatoes Retrospective (2023), John Astin states his performance as Gangreen was a little inspired by his father who was a real life scientist in charge of developing a death ray for the US government.
Gary Condit: a patron in the pizzeria. J. Stephen Peace, who co-wrote and co-produced the film, was a friend of Condit, and both were members of the California State Assembly. Former US Congressman Condit became a household name in 2001, when Chandra Levy, his intern and mistress, disappeared.