The names Ruff and Reddy come from U.S. president Zachary Taylor who was nicknamed "Old Rough and Ready".
This was the first television show produced by Hanna-Barbera.
Virtually all the voices on the show were supplied by Daws Butler and Don Messick. This is because at the time voice actors were paid by the recording session, regardless of how many voices they did during the session. This is also why female characters hardly ever featured on the show.
First H-B cartoon to be premiered on a prime-time channel.
The first cartoon to use the new sound effects produced by Hanna-Barbera productions, which were also used and recorded from Screen Gems Cartoons/UPA and Stooges sound effects for Columbia Pictures.