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1-46 of 46
- Dr. Masters' big day is at hand after 12 months of studies. Without Virginia as a voice of moderation will Bill's pitch hit the mark? Margaret Scully is confronted with her husbands homosexuality and investigates what is involved with his 'treatment'. Dr. Austin Langham has a job offer from L.A and the climax to the episode sees Virginia Johnson reading the notes from Dr. William Masters presentation at home in the rain, to hear a knock at the door.
- Virginia unearths Masters' troubled childhood during a secret rendezvous.
- Johnson, Masters, Libby and Keller wind up together at a party thrown by Art and Nancy. Pairings and perspectives shift as the night wears on, until the light of day exposes the consequences of the evening.
- William and Libby experience personal tragedy. Masters decides to pair Austin with a stranger. Virginia struggles with her parenting due to her long hours. Ethan's relationship with Vivian takes the next step, whether he likes it or not.
- Bill and Libby vacation in Miami after losing the baby. Virginia attends a visiting doctor's speech and decides to investigate one of the claims on her own. Austin struggles with the reason for his non-performance in the study.
- 2013–201656mTV-MA8.3 (479)TV EpisodeA television crew arrives at the clinic to document Masters and Johnson's work treating sexual dysfunction. Masters considers the publicity premature, and himself unsuitable as a television presence. Virginia deals with the fallout of having prioritized her work over her parenting when George argues to take their children on a trip with his new wife. Plus, Libby finds in Robert an appreciation for what she has to offer. And Langham realizes there's no way out of his sexual contract with Flo.
- 2013–201658mTV-MA8.3 (472)TV EpisodeMasters and Johnson feel ready to cure sexual dysfunction.
- Masters, Johnson, Logan and his wife gather in New York for a dinner in which agendas collide, truths are exposed and no relationship emerges unscathed. Back home, Libby faces an accusation that threatens her family's foundation.
- Johnson looks to get her relationship with Masters back on track while Masters does his best to find satisfaction elsewhere. Betty and Helen ready themselves for a new addition. Art and Nancy discuss the consequences of their party.
- Masters and Libby compile study information for hospital-wide presentation; DePaul and Johnson travel to a medical convention; Virginia's ex returns finds Ethan playing father to his children.
- After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson is forced to accept DePaul's choice to end her chemotherapy treatments. Gene uncovers the truth about Betty and Helen's relationship. Libby fires Coral after discovering she lied about Robert.
- On the heels of their disastrous dinner in New York, Masters and Johnson return to find their life's work in jeopardy while under the scrutiny of the press and their publisher in preparation for their new book.
- Virginia's parents arrive unannounced. Meanwhile, Libby and Masters discover Johnny has been bullied and look to fix it in their own ways. Plus, Johnson finds unexpected excitement in the scent study while Masters, looking to overcome his embarrassing departure from the university, takes on a promising fertility patient that could land him and Johnson back in good graces.
- Virginia and William ramp up their participation in the study. Libby bypasses William and pressures Ethan to resume the treatments. Austin and Margaret ramp up their tryst leading to differing expectations. Ethan decides to commit to Vivian.
- A former study participant comes forward with news of her pregnancy. Ethan learns he has been effectively fired, but not for the reason he thought.
- Virginia and Dr. Masters move on to filming involuntary reactions during the study, with Jane as usual being the first subject. Ethan reveals information about his heritage that threatens their relationship.
- Masters continues his study, but loses his gynecology practice; Coral's brother confronts Libby; Betty reunites with a former lover; Johnson tries to fix her relationship with DePaul.
- Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean for him, Johnson and the practice.
- Masters and Johnson go on the road and pose as a couple to investigate practices at a competing clinic. While Bill and Virginia are away, Art, Nancy and Langham take advantage of their absence to further their own agendas.
- Dr. William Masters, a successful doctor of obstetrics and gynecology, begins his controversial study of human sexuality. Dr. Masters recruits Virginia Johnson to be his secretary, but she quickly advances to be a valuable associate.
- Both Bill and Virginia have unexpected and unwelcome visitors at home. With the study back in the hospital, new participants are recruited. Ethan struggles to forget his feelings for Virginia.
- Virginia resumes pursuit of her undergraduate degree. Masters takes Virginia's suggestion and enlists the aid of a technician to construct a working camera to film the intimate workings during sexual intimacy.
- Masters learns of a rival study and calls in a public relations expert to help brand his work with Johnson. Virginia, having finally learned of Masters' sexual difficulties, is invigorated by the prospect of finding a cure. Determined to prove her worth to Robert, Libby canvases a tenement for a rent strike. Plus, Langham is stunned when Flo informs him that he has to have sex with her in order to keep his job. And Barbara and Lester connect over their shared sexual dysfunctions.
- Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace in one another.
- A woman pregnant with quadruplets comes to the hospital and Dr. Haas lobbies for the case. A female gynecologist joins the staff. Both Dr. Masters and his wife learn a secret and both get what they want.
- Following Bill's declaration in season 1 finale, Bill and Virginia resume their professional and personal relationship - both asserting it is to further the cause of their work. Virginia breaks the news to Ethan and Bill tries to be there for Libby and their new baby but finds it hard. Bill is struggling with getting his career back on track and Virginia is still working for Dr. DePaul but hungers for more. Scully is determined to succeed in his "therapy", but Margaret will bear no more illusions in her life.
- Johnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new post; and Betty tries to conceal her infertility from Gene, over Masters' objections.
- In the wake of Masters' discovery that Johnson has continued to have romantic relationships with other men, he becomes impotent without her knowledge and cuts off their sexual work together. He tries to keep his new clinic solvent over the course of three years by borrowing against his house, offering medical services to the hotel - and finally accepting money from his mother.
- Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters' attempt to remedy Lester's impotence by hiring a prostitute rattles him even further. Libby gets the third degree when she offers her eyewitness testimony regarding the beaten man. And Barbara Sanders wrestles with an unsettling diagnosis that exposes a chain of secrets and causes Masters and Johnson to clash over their treatment strategy.
- As Masters and Johnson face the press for the first time, they flashback to summer vacation, where Bill is finishing their book, Virginia faces parenting struggles, and Libby is pulling herself out of a depression. Season premiere.
- Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.
- Masters begins a new job at Memorial Hospital - under Betty's terms - only to find his boss insisting he leave Virginia behind in favor of a handpicked secretary. Johnson, meanwhile, still alienated at Maternity, is torn between pressing Masters to rehire her and staying by DePaul's side as her condition worsens.
- As a result of their spreading celebrity, Masters and Johnson take on a famous couple looking to reinvigorate their sex life. Meanwhile, Tessa learns what childhood with Edna Eshelman must have been like for Virginia. Plus, Masters attempts to connect with Johnny, but misses the mark entirely, and Libby furthers her involvement in Joy's life - with consequences that extend to Paul.
- Johnson objects to Masters' program after both Nora and Lester have missteps in the protocol. Meanwhile, as Libby's birthday approaches the men in her life are aiming to please. Plus, Tessa explores what sex really means to her.
- The Provost shuts down the research when he hears about the couples study and Masters is forced to move it elsewhere. Dr. Masters blames Virginia and fires her, but keeps her on until he can find a replacement.
- Johnson attempts to treat a woman on her own. Libby witnesses a hate crime.
- Masters consults unexpected advice in convincing Johnson to rededicate herself to the study and to him. A familiar face returns to the clinic for help. Meanwhile, Virginia is distracted by news of Henry and fails to notice Tessa trying to make sense of her home life. Libby confronts the truths of hers as she helps Paul and Joy pick up the pieces of their shattered lives.
- In the wake of their fallout, Masters and Johnson search for purpose in a world without one another and look to work as their personal lives crash down around them. Libby finds herself alone for the first time since her marriage and discovers some unexpected allies.
- Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and Virginia.
- Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single woman of the sexual revolution.
- The shock waves surrounding Masters and Johnson's first press conference begin to reverberate around their universe as the book nears its release date. Meanwhile, Masters takes on a powerful, high profile fertility patient with the help of a new doctor in the practice, while Virginia and Libby come to terms with Bill's role in their lives.
- Masters and Johnson's book is released and, while reviews are positive, the public's response causes unease around the office. The new spotlight on her mother starts to affect Tessa at school, while Libby does her best to maintain a social life outside of her friendship with Virginia. Meanwhile, Masters and Johnson look to old and new places to capitalize on their burgeoning fame.
- As Johnson jets away to Las Vegas with Dan Logan, Masters uses her absence to begin his surrogacy program. Meanwhile, Libby comes to terms with her current and past relationships. And Barton considers starting one of his own.
- Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights to Helen's baby.
- Libby tries to mask her feelings by setting Paul up with a friend. Meanwhile, Masters continues his surrogacy program, now under the critical eye of Johnson. And Lester volunteers as their first male surrogate.
- Masters and Johnson are interviewed by 'Newsweek' as they take on an exotic new patient. Meanwhile, Dan Logan tries to read Virginia. Plus, Libby and Paul deal with the fallout of exposed truths.