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A woman discovers that the organs of patients who die in a hospital are being harvested by a mortuary before the bodies are cremated for the hospital president to sell on the black market.

Danny helps a past girlfriend of his who is now a petty crook, but doesn't reckon on her taking up with a murderous bank robber and being an accessory to his crimes.

A gang, led by the vicious Hawkins, is executing a plot to steal $6 million. The group includes a bank employee and an alienated, long-time employee of a trucking company. The plan results in multiple deaths. Dan Williams leads the Five-O investigation because McGarrett is having to testify at a trial on the "Big Island."

Con-artists arrive in Hawaii and meet up with local thieves to plan a phony diamond con. When a wealthy tourist devastated by the con leaps to his death, McGarrett discovers he is one of many victims. As another angry victim seeking revenge and Five-O close in on the gang; the crooks turn on one another.

McGarrett receives a telephone call when he arrives at his office. The caller says that he intends to kill someone. The caller has also sent the lawman a key that will identity the intended victim. The other Five-0 detectives have received taunts and clues from the caller, including a photograph of Chin Ho's garage, and a note in the trunk of Danno's car. The caller continues to taunt McGarrett, who is desperate to learn the identity of the caller, and the identity of the intended victim.

A psychiatrist is tormented by a man calling himself Cerberus. Cerberus claims he was rejected for treatment and is determined to take revenge by extorting the psychiatrist. Cerberus, to show he means business, begins harassing the psychiatrist's patients, including a young man dying of a brain tumor and a suicidal woman. McGarrett & the Five-O must deal with this cunning and ruthless adversary.

A band of young radicals is killing ordinary people at random. Five-O consults an academic who is knowledgeable about such groups. The group then kidnaps Dan Williams and the academic, threatening to kill both men.

A man named Winkler goes berserk when approached by a television reporter doing a "man on the street" story. After his arrest, Five-O and HPD can find no evidence that Winkler even existed until seven years earlier. For Five-O, this is just the start of a complicated investigation full of shadowy figures and murky motives. Winkler, for example, has a number of aliases and a photographic memory. Eventually McGarrett & Co. uncover a plot to assassinate a Soviet defector.