After 6 Academy-Award nominations and no wins, Amy Adams is gritting her teeth to earn the gold in the upcoming Marielle Heller adaptation of Rachel Yoder’s magical realism novel, “Nightbitch.” The book and film tell the story of a stay-at-home mother whose domesticity turns ferocious as she slowly starts mutating into a dog. In a recent interview with Vanity Fair, Adams spoke on the transformation she undertook for the role and her reaction to reading the source material.

“It was so unique and otherworldly, and like nothing I’d ever read before,” Adams said of Yoder’s novel, which she tore through before it was even published. To option the rights to the book, Adams’ production company partnered with Annapurna Pictures, who she’d worked with on “The Master,” “Her,” “American Hustle,” and “Vice.”

“The thing I really attached to is this idea of loss of identity,” Adams said, continuing...