There is a lot of speculation regarding Johnny Depp's possible involvement in Tim Burton's Beetlejuice 2 and like everything else with his career, a Beetlejuice 2 Johnny Deppe appearance is at the same time both highly unlikely and entirely possible. Burton's second movie, the 1988 horror-comedy Beetlejuice, remains beloved and was his last film before his now-famous partnership with Johnny Depp began in 1990 with Edward Scissorhands. Beetlejuice 2 entered development in earnest in 2023 after years of rumors. One persistent Beetlejuice 2 rumor that's spread in various forms is that Depp was among Beetlejuice 2's cast.

With the 2023 news that Beetlejuice 2 was confirmed to be happening, the Johnny Depp casting rumors resurfaced, now interwoven with the ongoing saga surrounding his widely publicized legal issues with Amber Heard. The Beetlejuice sequel's past is checkered with numerous attempts to resurrect the "ghost with the most" for the big screen.