Wes Anderson has worked with many of the same actors over the years, and the Asteroid City cast is full of his regulars, but there are also a lot of new faces playing characters in the movie. Anderson's 11th feature is set in 1955 in a fictional American town in the desert. The plot involves the attendance of the Junior Stargazer convention in the titular location. Being home to a mysterious asteroid draws a lot of quirky tourists to the town too. To populate the town of Asteroid City during this time, the movie has assembled most of Anderson's regular troupe for a star-studded ensemble.

One famous face who is notably missing from the cast of Asteroid City is Bill Murray. The 2023 release is the first Anderson movie without an appearance from Bill Murray since his appearance in the director's sophomore feature, Rushmore. In fact, Murray has been in a record-setting nine Anderson films.