Jason Sudeikis and Rosario Dawson will lead an all-star virtual online table read of the holiday classic It’s a Wonderful Life to benefit The Ed Asner Family Center (Teafc), which promotes mental health and enrichment programs to children with special needs and their families.

The one-night-only event is set for Dec. 5, with a cast that also includes Mark Hamill, Martin Sheen, Mandy Patinkin, Lou Diamond Phillips, Phil Lamarr, Ben Mankiewicz, Ron Funches, Ed Harris, and Sudeikis’ real-life uncle George Wendt. The Cheers actor will play Uncle Billy to Sudeikis’ George Bailey.

The Asner benefit is presented in partnership with Turner Classic Movies and sponsored by MeTV, and this year also will honor Mike Darnell, President of Unscripted and Alternative Television at Warner Brothers, and his family. The cast will include Darnell’s daughter and Social Director of Teafc, Chelsea Darnell, autistic actors Spencer Harte and Domonique Brown along with neurodivergent...