Actor Hugh Laurie made a career out of his excellent comic timing, and this was carried into his titular character in the hit medical drama, House M.D.-- a role that won him numerous accolades. Greg Germann, too, has had an extensive career, especially on television, and played Tom Koracick in the long-running ABC medical drama, Grey's Anatomy.

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Both characters are rough on the surface bordering almost on the unkind, but both have much deeper personalities built and shaped through difficulties and tragedies in their respective pasts. While the Grey's writers didn't dig deep enough and underused Germann's talent, House M.D. explored the lead character's many eccentricities to its fullest extent.