Nat Geo has cast Tony Goldwyn and Daniel Dae Kim as the leads for Season 2 of “The Hot Zone,” which is focused on the anthrax attacks following 9/11.

“The Hot Zone” was originally intended as a limited series. But when Season 1, which was about Ebola, became the most-watched scripted series in the cable channel’s history, “The Hot Zone” became an anthology series.

As previously announced, Kelly Souders and Brian Peterson will return as executive producers for the “Anthrax” season. Principal photography is set to begin shortly in Toronto.

“The Hot Zone: Anthrax” takes place in 2001, just weeks after 9/11, when the United States was rocked by another deadly act of terrorism. Letters containing deadly anthrax spores were sent to unsuspecting victims in Florida, Washington, D.C. and New York, and the anonymous assault claimed five lives and spread panic throughout the U.S. Despite interagency turf wars and many false leads,...