Fresh off the horror hit “The Invisible Man,” Elisabeth Moss is re-teaming with Blumhouse. The Emmy-winning actress and her Love and Squalor Pictures production company are developing the still-unpublished book “Mrs. March” into a feature film, which Blumhouse will back.

Moss will also star in the film as the titular character, an Upper East Side housewife who starts to lose her grip on reality when she begins to suspect her novelist husband based the odious central character in his latest bestseller on her. Virginia Feito, the author of “Mrs. March,” will write the screenplay.

“I read Virginia’s novel in one sitting and was so captured by it I knew I had to make it and play Mrs. March,” said Moss. “As a character, she is fascinating, complex, and deeply human and I can’t wait to sink my teeth into her. Mrs. March is exactly the kind of engaging...