The Rachel Brosnahan-led indie “I’m Your Woman” has rounded out its cast and filming has commenced in Pittsburgh, Pa.

The actress, who is the streamer’s most decorated star thanks to her Emmy and Golden Globe-winning work on “The Marvelous Mrs. Maisel,” welcomes a slew of actors on the drama about a woman and her child on the run from the sins of her husband.

Marsha Stephanie Blake, British actor Arinzé Kene and Bill Heck (“The Ballad of Buster Scruggs”) have all joined the project in key roles. Frankie Faison, Marceline Hugot (“Julie & Julia”), and James McMenamin (“Orange is the New Black”) have signed on for supporting roles.

The film is directed by Julia Hart, and co-written by Hart and husband Jordan Horowitz. Hart was writer-director on the 2016 SXSW player “Miss Stevens,” starring Lily Rabe and then-undiscovered talents Timothee Chalamet and Lili Reinhart. She also helmed this...