Decades from now, long after the oceans have risen and humanity has descended into chaos, Paul Rudd will still be trolling Conan O’Brien with the same “Mac and Me” clip.

Fifteen years after first faking out the then-“Late Night” host with a clip from the derided 1988 “E.T.” ripoff, the actor swung by “Conan” to prank O’Brien yet again. Rudd’s latest Netflix series “Living with Yourself” joins the list of projects to get the vaunted “Mac and Me” bump on late night, joining a handful of McU entries, “Anchorman 2,” and the “Friends” finale (which initiated the tradition way back in 2004).

Every appearance starts off innocently enough, with Rudd discussing the particulars of the latest film or TV show he’s promoting, dropping in some pre-planned anecdote before throwing to a clip. Nearly without fail, that footage ends up being the same incredibly ridiculous scene from “Mac and Me,...