There will be no Season 5 for Fox’s The Last Man on Earth, starring Will Forte, which is being canceled after four seasons. The show is one of three comedy series canceled by Fox today, along with Brooklyn Nine-Nine and The Mick.

The Last Man on Earth quickly established a cult following but was never able to grow beyond niche appeal. Still, boosted by DVR viewing, the quirky comedy averaged a 1.2 adults 18-49 rating in Live+7, on par with The Mick and freshman La to Vegas, which had been looking promising for renewal. The high-concept comedy already cheated cancellation once, clinching a last-minute renewal last year.

From writer-producer Will Forte and directors/producers Christopher Miller and Phil Lord, The Last Man on Earth was a straight-to-series order. It chronicled the life and adventures of an average guy who inadvertently becomes humanity’s last hope. After a deadly virus swept the...