Oscar winner Marcia Gay Harden is trying her hand at something new. The actress has landed the lead role in NBC's latest comedy pilot, "Isabel."

Harden will play Francis, the matriarch of a "normal middle-class family that wrestles with the challenges of everyday life while raising a daughter (Sophia Mitri Schloss from 'Grimm') who has magical qualities," according to Entertainment Weekly.

"Isabel" will have Howard Busgang ("The Closer") and Tom Nursall ("Single White Spenny") as its showrunners.

This is the third time in the past four years that Harden has signed on for a TV pilot. Last year, she did ABC's sitcom "Smothered," and in 2008, she did CBS' "The Tower." But neither made it to air.

Could the magic "Isabel" prove that third time's the charm?

Harden is quite the accomplished actress of film, stage and television. Besides her Academy Award for "Pollock," she received a Tony Award for "God of Carnage,...