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Lupe from My 600-Lb Life lost over 400 pounds, but also faced relationship struggles and heartbreak. Lupe found new love after leaving her husband and boyfriend passed away, showcasing her resilience. Despite challenges, Lupe inspired many by not giving up and continuing her weight loss journey.

My 600-Lb. Life season 4 star Lupe Samano had a very successful and inspiring journey during the show, but what about her life since she completed filming? Lupe was 39 years old and 642 pounds at the beginning of her episode of one of the best reality TV shows. At the time, Lupe had been confined to her bed for over a decade. She sought help from renowned bariatric surgeon Dr. Younan Nowzardan, who is known as Dr. Now because she wanted to save her life. Her husband, Gilbert Donovan, had become more like a caretaker. While she won't appear on My 600-Lb Life season 12, there's still curiosity about Lupe after the show.

Donald Shelton, an early cast member of My 600-lb Life, regained weight due to a rare disorder called Guillain-Barré syndrome. Despite his setback, Donald is determined to achieve his goal weight and continues to follow a healthy diet. Donald is trying to raise funds to buy a van for himself and his mother, who both have disabilities, in order to improve their mobility.

My 600-lb Life introduced Donald Shelton during season 2 of one of the best reality TV shows, and it's time for an update. It's been over ten years since Donald made his reality TV debut. For the most part, Donald has tried his best to tell fans about his whereabouts and what he's been up to. His journey on the series was incredibly memorable, and so was his life after the show. As fans await My 600-Lb Life season 12, it's time to revisit one of the earliest cast members.

Henry Foots appeared on My 600-lb Life season 1, and there is curiosity about what happened to him when the cameras stopped rolling. There are different outcomes for the series' cast members. Some get their lives back and become inspirations, while others struggle to follow rigorous weight loss processes. For Henry, it was exciting to see how far he had come on the show.

It's been a while since My 600-lb Life season 1 premiered, so many are curious about what they are doing now. Melissa Morris lost nearly 450 pounds, becoming a true success story, especially after she started working with the series' renowned celebrity surgeon, Dr. Nowzaradan, also known as Dr. Now. Donald Shelton lost nearly half of his body weight through the process, but he continues to live with a rare immune system disorder. Tragically, Henry, along with Ashely Randall, passed away after filming My 600-lb Life.

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What an inspiring update! Amber Rachdi from My 600-lb Life was just 23 years old when her episode aired in 2015. At the time, she weighed 657 pounds and admitted she felt like a "nasty, yucky monster." Her anxiety caused her to overeat and she needed assistance with even the most basic tasks. Back then, she could only stand on her legs for 30 minutes, which was why Amber decided to seek treatment. On the show, fans watched her lose 20 pounds to become a patient for gastric bypass surgery. Amber's family moved to Houston with her so she could be closer to her doctor. (Photo Credit: TLC) When Amber was five years old, she weighed nearly 160 pounds and recalled having to be weighed on a scale for the wheelchair-bound at 16. She openly admitted that she had an eating disorder, but unlike anorexia, she couldn't stop eating. Despite her family enabling her and her father's comments about weight gain,...

Way to go, Chad Dean! The former My 600-lb Life star has seriously slimmed down since fans first saw him on the hit TLC series back in January 2016. At 700 pounds, the truck driver was forced to do something drastic or he risked possible death. After undergoing gastric bypass surgery, the former reality star dropped 260 pounds in a year, but he almost permanently damaged the area where his stomach meets his intestines in the process. (He stopped taking his prescribed medication because of its cost). Luckily, his Houston-based surgeon, Dr. Younan Nowzaradan, was able to reverse the damage, but he was furious with Chad for not following orders. At the start of the show, Chad was so morbidly obese that he relied on his wife Ayesha and their two children Taqua and JoJo to wait on him hand and foot. "It's not what my kids deserve," he said at the time.

TLC's My 600-lb. Life shows its subjects at critical stages of obesity, but mercifully, it seems like only two of the show's stars have died. And we just witnessed one of those sad endings on the reality show: Robert Buchel died on Nov. 15, with his episode airing posthumously on Feb. 28. In five months, this man from Forked River, NJ, lost 340 of his 840 pounds, Starcasm reports, but he developed a painkiller addiction following a lymphedema excision. And in November, as he filmed his episode, Robert suffered a fatal heart attack. "I lost my best friend and the person I was supposed to spend the rest of my life with," fiancé Kathryn Lemanski said on the show. "He told me, 'I don't think I'll make it through the night. I love you and I always will.'" In a Facebook post, Kathryn added, "The only consolation I have right now is...

Tamy Lyn Murrell, the latest subject of My 600-lb Life, no longer loves her husband, and the feeling is mutual. But at the start of the TLC reality show's March 7 installment, they were still married and living together because Tamy couldn't fend for herself like she did in her youth. As the youngest child in her family by 11 years, Tamy spent many of her childhood years as an only child, in effect. Though she was a "pretty normal size" as a young girl, those formative years weren't easy for her, especially because peers would make fun of her stutter. Then, when she was 8, she watched her father collapse to the kitchen floor and die of a heart attack. "After my father passed away, my life was never the same," she said in her episode. "My mom just fell apart. She had a hard time getting out of bed, and she went into a deep depression.