- She once auditioned for Downton Abbey (2010) and delivered what she felt was a heartfelt performance, but the producers thought she was too funny for the series.
- She was the bookmakers's favourite to replace Peter Capaldi as the Doctor in Doctor Who (2005), which would have made her the first woman to play the part.
- She admitted that before auditioning for Solo: A Star Wars Story (2018), she has never watched any Star Wars movie at all, and therefore had no idea what a droid was. She assumed that her character would be a human and delivered her lines accordingly during the audition. The directors liked her performance, but they asked her to perform her lines a bit more "droid-y", which she did after being explained what a droid is. However, the directors preferred her initial non-droid performance, which got her the part.
- Is the only person to have won an Emmy SAG Bafta and Golden Globe for the same TV performance in Fleabag.
- In a relationship with writer-director Martin McDonagh since 2018.
- Is a co-writer for the screenplay of the James Bond movie No Time to Die.
- Counts writer-producer Vicky Jones as one of her best friends.
- Her "Outstanding Lead Actress in a Comedy Series" Emmy for Fleabag (2016) was presented to her by Stephen Colbert (Microsoft Theater Los Angeles / September 22, 2019).
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