On November 10, 2015, Braxton discovered that she had several pulmonary emboli in her lungs. The illness forced her to withdraw from Dancing with the Stars (2005).
On an episode of The Real (2013), Braxton revealed that she suffered from vitiligo.
In October 2017, Braxton filed for divorce from Vince Herbert, citing "irreconcilable differences" and is seeking joint custody of their son.
On April 29, 2019, her niece Lauren Braxton, older brother Michael Conrad Braxton Jr.'s daughter, passed away from heroin and fentanyl intoxication at age 24.
Her older sister Traci Braxton passed away from esophageal cancer on March 12, 2022, only three weeks away from what would have been her 51st birthday on April 2.
On July 16, 2020, Braxton was hospitalized following a suicide attempt.