- Father: Clois, mother: Lourdes.
- She is half-Irish-American and half-Filipino and was born in the Philippines. She has an older brother who lives in the United States.
- In September 2005 she signed a three year management contract with Viva Entertainment. Her contract with Viva is for eight pictures with the Film company.
- Her first showbiz boyfriend was Paolo Contis who was also her first Love Team on the defunct teen drama Tabing Ilog.
- Desiree Del Valle and her second showbiz boyfriend met on the popular prime time drama Sana'y Wala Ng Wakas.
- Her Filipina mother Lourdes del Valle comes from Lopez, Quezon, Philippines. And her del Valle family still maintains roots in Lopez, Quezon, Philippines.
- Her career was officially launched as she was part of ABS-CBN's Star Circle Batch 7 which was launched on the popular Sunday variety show A.S.A.P.!
- Tuli (2005) was her first film for Viva Films. And was the first film for which she top billed. In Tuli (2005) she portrayed the role of Daisy.
- Her marriage to lesbian Elaine Crisostomo in a US wedding sparked a controversy in the Philippines, a conservative country.
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