- Father, Kevin Smith, named her after the Joker's sidekick "Harley Quinn/Harleen Quinzell" from "Batman".
- Appears in Jay and Silent Bob Strike Back (2001) as Baby Silent Bob, the role her father, Kevin Smith, is famous for playing as an adult.
- Harley Quinn is real-life best friends with her Yoga Hosers (2016) co-star, Lily-Rose Depp. The two met in Kindergarten at the Hollywood Schoolhouse.
- Plays bass guitar.
- Harley Quinn is named after the Batman character. Her father, Kevin Smith, is a self-proclaimed fanatic and even runs a podcast called "Fat Man on Batman".
- Daughter of Kevin Smith and Jennifer Schwalbach Smith.
- Plays bass for the bubblegum pop band The Tenth. They have an EP "Boys We Don't Know" and their debut album "Dunes" which came out in 2019. In addition to playing bass, Smith also sings.
- Harley is a Disney lover. She frequents goes to Disneyland often in her home state of California.
- She has appeared in five films directed by her father Kevin Smith: Jay and Silent Bob Strike Back (2001), Jersey Girl (2004), Clerks II (2006), Tusk (2014) and Yoga Hosers (2016), and in one episode of her father' TV show, Masters of the Universe: Revelation (2021).
- Granddaughter of Donald E. Smith and Grace Smith.
- Niece of Virginia Smith.
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