- The Harris County Institute of Forensic Sciences ruled that McCole's death was accidental. The "combined toxic effects of hydrocodone and difluoroethane with carisoprodol" were listed as the main cause of death. Difluoroethane is commonly found in computer duster aerosol spray cans and is sometimes used in huffing. (October 2014)
- Her favorite character that she played was Susan in The Patriot (2000).
- On July 19, 2014, McCole Bartusiak was found dead in her apartment behind her parents' Houston home. Her mother told CNN and the Associated Press that the actress was found by her boyfriend, sitting up in her bed; she began CPR on her daughter before paramedics arrived, who then worked "for 45 minutes" to no avail. Helen McCole Bartusiak said Skye "had been healthy and did not drink or do drugs", and had recently been suffering from epileptic seizures and that this likely played a role in her death.
- Owned a Charlie's Angels (2000) doll signed by her Riding in Cars with Boys (2001) co-star Drew Barrymore.
- Was friends with fellow actors Abigail Breslin and Spencer Breslin.
- Made her own purses, which she took to premieres and other events.
- Was friends with her Don't Say a Word (2001) and Riding in Cars with Boys (2001) co-star Brittany Murphy.
- Was a talented singer.
- Had directed 2 film shorts and was in the stages of directing her first feature at the time of her death.
- Had a Maltese named Pippa, which she adopted in April 2001. It was named after her character in Storm of the Century (1999).
- Was named after the Isle of Skye, in Scotland.
- Her inspiration was her mother, Helen McCole Bartusiak, who was an acting coach.
- Played the young Charlie McGee in the TV sequel to Firestarter (1984), a role originated by Drew Barrymore, her co-star in Riding in Cars with Boys (2001).
- Favorite movies were The Princess Bride, Walk the Line, and The Insider.
- Acted alongside Hilary Swank in the play "The Miracle Worker", written by William Gibson. [March 2003]
- Did all of her own stunts in Firestarter: Rekindled (2002).
- Her Don't Say a Word (2001) co-star Conrad Goode taught her how to play blackjack and poker.
- When she was younger, she made short films starring her dog Pippa.
- Was friends with fellow actress Hallee Hirsh, whom she met at the 2004 Sundance Film Festival.
- Graduated from Laurel Springs High School in 2010.
- At the time of her death she had two dogs, Milo and Tex.
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