- Son, Baylee Littrell, was recently diagnosed with Kawasaki disease.
- Kevin called Brian up in his US history class and he asked him to join the Backstreet Boys in 1993, at the age of 18.
- Released a Contemporary Christian CD in the spring of 2006.
- He had opened heart surgery in 1998 to correct a Ventricular Septal Defect in his heart. The defect was located in the lower left and right pumping chambers of his heart.
- Met his wife Leighanne Littrell on the set of Backstreet Boys music video "As Long As You Love Me" on June 15, 1997. She played a girl named Donna in the video.
- Signed a record deal with a Christian Label. (December 2004)
- Released a Christian solo song "In Christ Alone", found in the WOW #1s CD. (February 2005)
- Cousin of Kevin Scott Richardson.
- Brian suffers from Muscle Tension Dysphonia. This is a condition that causes the sound and feel of his voice to change due to extreme muscle tension in and around the voice box. As a result it causes his voice to regularly stop performing efficiently.
- Brian and Backstreet Boys group mate, Kevin Scott Richardson, are first cousins. Kevin's mother, Anne, is the older sister of Brian's father, Harold.
- Their new album (Millennium) broke the record for most sales in the first week - previously held by Garth Brooks - by selling over 1 million copies in the USA alone.
- Member of boy group, Backstreet Boys.
- Grew up in Lexington, Kentucky and attended Tates Creek Senior High School. Still has family living in Lexington and returns often to participate in local events.
- His ex-girlfriend Samantha Stonebraker wrote a book called Backstreet Secrets Only A Girlfriend Can Tell.
- Welcomed first child, son Baylee Littrell (Baylee Thomas Wylee Littrell), on November 26, 2002.
- Currently promoting the Backstreet Boys' new album, their fifth, in a variety of countries such as Mexico and China. (October 2004)
- On May 2, 2005, CD, Welcome Home, came out. (May 2005)
- Brian, Nick Carter, Kevin Scott Richardson, A.J. McLean and Howie Dorough (The Backstreet Boys) have finished their fifth album, due fall 2005. (January 2005)
- Son Baylee has appeared in the Broadway musical, "Disaster".
- Currently on tour with the Backstreet Boys and released the group's newest single, "Incomplete". (April 2005)
- Almost had a sister before his mother sadly miscarried before she was born.
- Featured in Casting Crowns' 20th-anniversary album, singing "In the Hands of The Potter".
- Will be releasing a second Christian album sometime this year or next year.
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