- The actual proposal of Nathan West to Chyler Leigh was filmed and is an "Easter Egg" hidden on the DVD of Not Another Teen Movie.
- Her name is pronounced "kai-ler lee".
- At only 23 years old, she has already been a part of nine different TV series.
- Has a son, Noah Wilde, born in December 2003 and two daughters Taelyn Leigh born in September 2006, and Anniston Kae born on May 7, 2009.
- Portrayed the sister of the title character in Grey's Anatomy (2005), who died after an airplane crash. In Supergirl (2015) she is again the sister of the title character and, in the Pilot, is saved by her from perishing in an airplane crash.
- Chyler Leigh also makes music with her husband Nathan West (East of Eli), under the name "WestLeigh".
- Has a huge sprawling tattoo located on her lower back. The design is some type of artsy cosmic inspired masterpiece, which includes two creatures, stars and a night sky background.
- She has played the same character (Alex Danvers) in four different series: Arrow (2012), The Flash (2014), Supergirl (2015) and DC's Legends of Tomorrow (2016).
- After only two episodes of Girls Club (2002) had aired, Leigh received a personal phone call from David E. Kelley informing her of the show's cancellation and his desire to bring her forward to his already established series The Practice (1997). With only a matter of weeks between shows, Leigh was at work on the set of ABC's The Practice (1997) as a new series regular. (February 2003)
- Chyler and her husband welcomed their second daughter, Anniston Kae, on May 7, 2009, seven days after wrapping the fifth season of Grey's Anatomy. Anniston Kae is their third child.
- Expecting her third child, although the pregnancy will not be written into her "Grey's Anatomy" storyline. (People magazine, 29 December 2008).
- Younger sister of actor Christopher Khayman Lee.
- The "Stuff" magazine cover she did with Mia Kirshner was the first time that magazine ever featured multiple people on the cover.
- Ranked #41 in Stuff magazine's "102 Sexiest Women in the World" (2002).
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