- Sirena never missed a performance of "I Love Lucy Live On Stage" and there were over 550 of them.
- A student of the famed acting coach Larry Moss and co-star in his documentary, The Process, which investigates and encourages a clear and expansive connection between actors and directors.
- Sirena Irwin was mentored by legendary Animation Director/Casting Director, Andrea Romano. Their relationship began when they were both working on SpongeBob SquarePants and grew to what became a nearly 2-year mentorship before Ms. Romano handed over various shows to Sirena in order to retire early.
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