- Son of Patty Duke and John Astin.
- Younger half-brother of actor Sean Astin.
- Lost the top part of his right ear in a car accident.
- Dominic Monaghan was his roommate for a while. Mackenzie later made a guest appearance on Dominic's TV show, Lost (2004).
- Has three other half siblings: David, Allen and Ashley.
- Uncle of actress Ali Astin, Elizabeth Louise Astin and Isabella Louise Astin.
- He and his brother, Sean Astin, both guest-starred in Season 9 of NCIS (2003). Mackenzie was in the episode, Life Before His Eyes (2012), and Sean was in The Tell (2012).
- Was accepted to Johns Hopkins University, but did not enroll.
- Writes, makes and stars in his own Super 8 films.
- He is of English, Irish, Scottish, and German descent.
- Brother-in-law of producer Christine Astin.
- Nephew of Ray Duke.
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