18 wins & 25 nominations
- 2012 Nominee ALMA Award
- Favorite Female Music Artist
- 1999 Winner ALMA Award
- Outstanding Host in a Variety/Music/Comedy Special or Series
- 1999 Nominee ALMA Award
- Outstanding Performance by Individual in a Music Series or Special
- 2000 Winner Blockbuster Entertainment Award
- Favorite Song from a Movie (Internet Only)
For the song "Music of My Heart".
- 2022 Nominee Daytime Emmy
- Outstanding Informative Talk Show Host
Shared with: Emily Marie Estefan · Lili Estefan - 2021 Nominee Daytime Emmy
- Outstanding Informative Talk Show Host
Shared with: Emily Marie Estefan · Lili Estefan
- 2002 Nominee Grammy
- Best Dance Recording
For the song "Out of Nowhere"Shared with: Emilio Estefan Jr. · Gustavo Celis - 2001 Winner Grammy
- Best Traditional Tropical Latin Album
For "Alma Caribeña"Shared with: Robert Blades · Emilio Estefan Jr. · George Noriega · Scott Canto · Gustavo Celis · Javier Garza · Mauricio Guerrero · Sebastian Krys · Freddy Piñero Jr. - 2000 Nominee Grammy
- Best Pop Collaboration with Vocals
For "Music Of My Heart"Shared with: Justin Timberlake · *NSYNC
- 1996 Winner NCLR Bravo Award
- Outstanding Performance by a Female in a Variety or Music Series/Special
- 1990 Winner VMA
- International Viewer's Choice: MTV Internacional
- 2008 Winner Latin Grammy Award
- Best Tropical Song
For "Píntame de Colores" artist: Gloria EstefanShared with: Emilio Estefan Jr. · Alberto Gaitán - 2008 Nominee Latin Grammy Award
- Best Long Form Music Video
For "90 Millas"Shared with: Emilio Estefan Jr. - 2008 Winner Latin Grammy Award
- Person of the Year
- 2000 Winner Latin Grammy Award
- Best Short Form Music Video
Shared with: Emilio Estefan Jr. · Douglas Friedman
- 1994 Nominee American Music Award
- Favorite Pop/Rock Female Artist
- 1989 Winner American Music Award
- Favorite Pop/Rock Band/Duo/Group
Shared with: The Miami Sound Machine
- 1996 Winner Premio Lo Nuestro
- Female Artist of the Year - Pop
- 1994 Winner Premio Lo Nuestro
- Female Artist of the Year - Pop
- 1991 Nominee Premio Lo Nuestro
- Female Artist of the Year - Pop
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