Melissa McCarthy and Billy Gardell in Mike & Molly (2010)

Melissa McCarthy, Maya Rudolph, and Ben Falcone in Life of the Party (2018)

Melissa McCarthy and Ben Falcone in Life of the Party (2018)

John August and Melissa McCarthy in The Nines (2007)

Amy Adams, Melissa McCarthy, Ben Falcone, and Gal Gadot at an event for 82nd Golden Globe Awards (2025)

Melissa McCarthy and Ben Falcone at an event for 82nd Golden Globe Awards (2025)

Melissa McCarthy at an event for 82nd Golden Globe Awards (2025)

Melissa McCarthy and Octavia Spencer at an event for The Oscars (2024)

Melissa McCarthy at an event for The Oscars (2024)

Melissa McCarthy in 82nd Golden Globe Awards (2025)

Melissa McCarthy and Ben Falcone in Melissa McCarthy & Ben Falcone (2024)

Jerry Seinfeld, Jim Gaffigan, and Melissa McCarthy in Unfrosted (2024)

Jerry Seinfeld, Andy Daly, Jim Gaffigan, Max Greenfield, Melissa McCarthy, Ken Narasaki, Amy Schumer, Michael Joseph Pierce, and Drew Tarver in Unfrosted (2024)

Jerry Seinfeld, Fred Armisen, Jim Gaffigan, and Melissa McCarthy in Unfrosted (2024)

Melissa McCarthy and Halle Bailey in The Little Mermaid (2023)

Melissa McCarthy in The Little Mermaid (2023)

Melissa McCarthy and Ben Falcone in Watch What Happens Live with Andy Cohen (2009)

Melissa McCarthy in Saturday Night Live (1975)

Melissa McCarthy and Chris O'Dowd in The Starling (2021)

Bobby Cannavale, Melissa McCarthy, Luke Evans, Samara Weaving, and Melvin Gregg in Earth Day (2021)

Melissa McCarthy and Pom Klementieff in Thunder Force (2021)

Melissa McCarthy and Octavia Spencer in Thunder Force (2021)

Albert Brooks, John Lithgow, Leslie Mann, Melissa McCarthy, Paul Rudd, and Jason Segel in This Is 40 (2012)

Rose Byrne, Melissa McCarthy, Maya Rudolph, Wendi McLendon-Covey, Kristen Wiig, and Ellie Kemper in Bridesmaids (2011)