Sean Hayes, Eric McCormack, Debra Messing, and Megan Mullally in Will & Grace (1998)

Meg Ryan, Jada Pinkett Smith, Annette Bening, and Debra Messing in The Women (2008)

Barney Cheng and "Hollywood Ending" cast, distributors luncheon, Hotel Martinez, 55th Cannes Film Festival.

Seth Green, Jason Lee, Eric McCormack, Debra Messing, Steve Carell, Shane McRae, Josh Cooke, and Todd Grinnell in Will & Grace (1998)

Alyssa Milano, Debra Messing, Isaac Mizrahi, Georgina Chapman, and Anne Fulenwider in Project Runway All Stars (2012)

Robert De Niro, Debra Messing, Irwin Winkler, Jason Sosnoff, and Charles Winkler at an event for The Alto Knights (2025)

Steven Spielberg and Debra Messing at an event for Ambassadors (2013)

Natasha Lyonne, Debra Messing, and Megan Mullally at an event for Will & Grace (1998)

Whoopi Goldberg, Angela Bassett, and Debra Messing

Debra Messing at an event for The 24th Annual Critics' Choice Awards (2019)

Debra Messing at an event for 2019 Golden Globe Awards (2019)

Debra Messing and Ellen Pompeo in Debra Messing & Ellen Pompeo (2025)

Eric McCormack and Debra Messing in Will & Grace (1998)

Woody Allen, Téa Leoni, and Debra Messing in Hollywood Ending (2002)

Woody Allen and Debra Messing in Hollywood Ending (2002)

Judy Davis, Debra Messing, Reuben Jackson, and Michael Lerner in Celebrity (1998)

Alyssa Milano, Debra Messing, Isaac Mizrahi, and Georgina Chapman in Project Runway All Stars (2012)

Alyssa Milano and Debra Messing in Project Runway All Stars (2012)

Debra Messing and John Cho in Searching (2018)

Debra Messing and Steven Michael Eich in Searching (2018)

Ric Sarabia, Debra Messing, and John Cho in Searching (2018)

Debra Messing and Ben Cain in Searching (2018)

Heather Locklear, Dermot Mulroney, Debra Messing, Hilary Duff, Chris Noth, and Aria Wallace in The Wedding Date (2005)