John Stamos, Dana Sparks, and Lori Loughlin in Full House (1987)

John Stamos and Lori Loughlin in Full House (1987)

John Stamos, Candace Cameron Bure, Dave Coulier, Lori Loughlin, Dan Moriarty, Bob Saget, and Jodie Sweetin in Full House (1987)

Dulé Hill, Lori Loughlin, and James Roday Rodriguez in Psych (2006)

Lori Loughlin and Jack Wagner in When Calls the Heart (2014)

Lori Loughlin in When Calls the Heart (2014)

Shawn Christian, Merrin Dungey, Ryan Kwanten, Lori Loughlin, Jesse McCartney, Kay Panabaker, Zac Efron, Nick Benson, and Taylor Cole in Summerland (2004)

Shawn Christian, Merrin Dungey, Ryan Kwanten, Lori Loughlin, Jesse McCartney, Kay Panabaker, Nick Benson, and Taylor Cole in Summerland (2004)

Lori Loughlin in When Calls the Heart (2013)

Jean Smart, Lori Loughlin, and Poppy Drayton in When Calls the Heart (2013)

Mary-Kate Olsen, John Stamos, Candace Cameron Bure, Lori Loughlin, Bob Saget, Jodie Sweetin, Blake Tuomy-Wilhoit, and Dylan Tuomy-Wilhoit in Full House (1987)

Corbin Bernsen and Lori Loughlin in Psych (2006)

Lori Loughlin and Shenae Grimes-Beech in 90210 (2008)

Lori Loughlin and Ryan Eggold in 90210 (2008)

Ted Danson and Lori Loughlin in Curb Your Enthusiasm (2000)

Lori Loughlin in Curb Your Enthusiasm (2000)

Lori Loughlin and Jodie Sweetin in Full House (1987)

Victor Webster and Lori Loughlin in Homegrown Christmas (2018)

Lori Loughlin, Pascale Hutton, and Erin Krakow in When Calls the Heart (2014)

David Arquette, Jonathan Silverman, Kelly Hu, Greg Germann, Lori Loughlin, and Jackson Bond in In Case of Emergency (2007)

David Arquette and Lori Loughlin in In Case of Emergency (2007)

Lori Loughlin in In Case of Emergency (2007)

Kelly Hu and Lori Loughlin in In Case of Emergency (2007)

Greg Germann and Lori Loughlin in In Case of Emergency (2007)

Andrea Barber, Candace Cameron Bure, Dave Coulier, Lori Loughlin, and Jodie Sweetin in Fuller House (2016)

Lori Loughlin, Hrothgar Mathews, and Daniel Smith Arnold in When Calls the Heart (2014)

Keanu Reeves and Lori Loughlin in The Night Before (1988)

Lori Loughlin and Shannon Presby in The New Kids (1985)

Kelly Preston, C. Thomas Howell, and Lori Loughlin in Secret Admirer (1985)

Jim Carrey, William McNamara, and Lori Loughlin in Doing Time on Maple Drive (1992)

James Spader and Lori Loughlin in The New Kids (1985)

Mary-Kate Olsen, John Stamos, Candace Cameron Bure, Dave Coulier, Lori Loughlin, Bob Saget, and Jodie Sweetin in Full House (1987)

Ashley Olsen, John Stamos, Candace Cameron Bure, Dave Coulier, Lori Loughlin, Bob Saget, and Jodie Sweetin in Full House (1987)

Ashley Olsen, Mary-Kate Olsen, John Stamos, Andrea Barber, Candace Cameron Bure, Dave Coulier, Lori Loughlin, Bob Saget, Jodie Sweetin, Blake Tuomy-Wilhoit, Dylan Tuomy-Wilhoit, and Scott Weinger in Full House (1987)