Rumpelstiltskin tricks a mid-life crisis burdened Shrek into allowing himself to be erased from existence and cast in a dark alternate timeline where Rumpelstiltskin rules supreme.
After Po is tapped to become the Spiritual Leader of the Valley of Peace, he needs to find and train a new Dragon Warrior, while a wicked sorceress plans to re-summon all the master villains whom Po has vanquished to the spirit realm.
Manny, Diego, and Sid embark upon another adventure after their continent is set adrift. Using an iceberg as a ship, they encounter sea creatures and battle pirates as they explore a new world.
After one experiment, Johnny turns into a monster and everyone else becomes human. Now it has to be seen whether they will be able to reverse this experiment.