Gru, a criminal mastermind, adopts three orphans as pawns to carry out the biggest heist in history. His life takes an unexpected turn when the little girls see the evildoer as their potential father.
When a new criminal comes to town, the Anti-Villain League decides to hire Gru in order to fight him off. While Gru initially refuses, he eventually agrees after his aide goes back to his evil ways.
Minions Stuart, Kevin, and Bob are recruited by Scarlet Overkill, a supervillain who, alongside her inventor husband Herb, hatches a plot to take over the world.